Journal Name: WIREs mechanisms of disease
Journal Type: Q1
ISSN: 26929368
Country: United States
Subject Area and Category: Biochemistry, Genetics and Molecular Biology Cell Biology Medicine Medicine (miscellaneous)
Publisher: John Wiley and Sons Inc
Research Ranking: 168
Publication Type: Journals
H-Index: 86
Coverage: 2021-2025
Editors-in-Chief: Justus MB Anumonwo
Research Impact Score: 5.9
Impact Factor: 4.6
SCIMAGO SJR: 1.681
APC Cost: $4,650 USD
Submission Link: https://wires.onlinelibrary.wiley.com/hub/for_authors
Contact Email: sysbio@wiley.com
Address: Washington State University. PO Box 645610. Pullman, WA 99164-5610
Overview
WIREs Mechanisms of Disease is a premier interdisciplinary journal that delves into the biological and molecular underpinnings of human disease. As a part of the respected Wiley Interdisciplinary Reviews (WIREs) series, this journal aims to bridge the gap between basic biomedical research and clinical application. By offering in-depth, high-quality review articles, WIREs Mechanisms of Disease supports researchers, clinicians, and academics seeking to understand disease processes at the mechanistic level.
The journal focuses on synthesizing knowledge across fields such as molecular biology, genetics, immunology, pathology, and systems biology. Articles published in WIREs Mechanisms of Disease go beyond surface-level descriptions to explore the intricate cellular and biochemical pathways that drive disease onset, progression, and response to treatment. This holistic approach enables readers to grasp how genetic mutations, environmental factors, and molecular signaling intersect to influence health outcomes.
The editorial team includes distinguished experts in various domains of disease biology, ensuring each article is both scientifically rigorous and highly accessible. Content is peer-reviewed and curated to maintain academic integrity while encouraging readability for a broad audience, from early-career scientists to seasoned clinicians.
What makes WIREs Mechanisms of Disease particularly valuable is its commitment to clarity, depth, and relevance. Each review article is structured to provide historical context, current perspectives, and future directions, helping readers stay ahead of emerging trends and breakthroughs. Regular topics include cancer biology, neurodegeneration, metabolic disorders, autoimmune diseases, infectious disease mechanisms, and more.
SEO-wise, WIREs Mechanisms of Disease stands out as a trusted source for search queries related to disease pathogenesis, molecular medicine, and translational research. Whether you’re looking to understand how genetic mutations lead to cancer or how immune responses contribute to chronic illness, this journal offers authoritative and comprehensive insights.
Ideal for biomedical researchers, healthcare professionals, and policy makers, WIREs Mechanisms of Disease contributes significantly to the global dialogue on disease mechanisms, diagnosis, and potential therapies. It is indexed in major databases and boasts a growing readership among the academic and clinical communities.
About
The scope of WIREs Mechanisms of Disease encompasses a wide spectrum of biomedical disciplines focused on unraveling the complex molecular and cellular mechanisms behind human diseases. The journal is designed to serve as a knowledge hub where fundamental discoveries in biology intersect with translational medicine and clinical application.
At its core, the journal seeks to answer one critical question: What are the molecular drivers of disease? To address this, WIREs Mechanisms of Disease publishes authoritative review articles that integrate insights from fields such as molecular genetics, immunology, cell signaling, microbiology, epigenetics, systems biology, and pharmacology.
The journal welcomes reviews on both common and rare diseases, with special attention to emerging research areas like precision medicine, gene editing, and personalized therapeutics. Each article emphasizes mechanistic understanding—explaining how dysfunction at the molecular or cellular level leads to specific disease phenotypes. By doing so, it fosters a deeper comprehension of disease pathology, which is essential for developing targeted interventions.
Typical topics covered within the journal's scope include:
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Molecular basis of cancer and tumorigenesis
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Neurodegenerative disorders and neuronal signaling
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Inflammatory pathways in autoimmune and infectious diseases
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Genetic and epigenetic regulation of disease expression
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Metabolic and mitochondrial disorders
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Emerging therapeutic mechanisms and resistance pathways
What distinguishes WIREs Mechanisms of Disease from other biomedical journals is its focus on review articles rather than original research. These reviews synthesize vast amounts of data into coherent narratives, making complex topics more digestible for readers from varied scientific backgrounds. This curated approach ensures the content is not only accurate but also highly relevant and future-focused.
Importantly, the journal’s scope includes both disease-specific reviews and broader thematic articles exploring methodologies, model systems, and theoretical frameworks used to study disease mechanisms. Interdisciplinary contributions that bridge gaps between biology, computational modeling, and clinical research are especially encouraged.
The journal’s readership includes biomedical scientists, clinicians, educators, and graduate students, making it a vital resource for staying current in the fast-moving landscape of disease research. As a part of Wiley’s WIREs series, the journal adheres to high standards of scholarly publishing and editorial excellence.
From an SEO perspective, the scope of WIREs Mechanisms of Disease aligns well with keywords such as “molecular mechanisms of disease,” “biomedical research reviews,” “disease pathogenesis,” and “interdisciplinary disease research.” The journal serves as an ideal destination for those searching in-depth analyses of the biological basis of human diseases.
Scope
WIREs Mechanisms of Disease is a cutting-edge, peer-reviewed journal dedicated to exploring the intricate molecular and cellular mechanisms that drive human disease. Part of the highly respected Wiley Interdisciplinary Reviews (WIREs) series, the journal offers expertly crafted review articles that integrate knowledge from across the life sciences to provide a unified view of disease biology.
Established to serve a diverse audience of biomedical researchers, healthcare professionals, and translational scientists, WIREs Mechanisms of Disease focuses exclusively on reviews—distilling complex research findings into comprehensive, readable formats. Each article is written by leading experts and rigorously peer-reviewed to ensure accuracy, depth, and relevance.
The journal’s mission is to advance understanding of disease processes at the molecular level and support the development of novel therapeutic strategies. By bridging the gap between basic science and clinical application, WIREs Mechanisms of Disease promotes translational insights that can inform diagnostics, prognostics, and treatment approaches.
One of the defining features of the journal is its commitment to interdisciplinary scholarship. Articles frequently span multiple fields, incorporating perspectives from genetics, molecular biology, immunology, pathology, bioinformatics, and more. This integrated approach reflects the real-world complexity of disease and fosters a more holistic understanding of human health.
WIREs Mechanisms of Disease is known for its thematic diversity. From cancer signaling pathways and immune system dysfunction to metabolic syndromes and rare genetic disorders, the journal covers a wide range of topics, all unified by a central focus on biological mechanisms. It also spotlights innovative technologies such as CRISPR, single-cell analysis, and omics-driven research that are reshaping the study of disease.
For readers, the journal serves as a vital resource for staying informed about the latest advances in disease research. Each review not only summarizes current knowledge but also identifies knowledge gaps and proposes directions for future investigation. This makes WIREs Mechanisms of Disease particularly useful for researchers designing new experiments or exploring novel therapeutic targets.
In terms of SEO, the journal is optimized for search queries such as “mechanisms of disease,” “molecular disease reviews,” “biomedical review journals,” and “disease pathogenesis articles.” Its content consistently ranks well due to its scholarly authority, expert authorship, and relevance to current medical and scientific challenges.
Whether you’re a bench scientist seeking clarity on disease mechanisms, a clinician interested in the latest translational insights, or a student aiming to grasp the foundations of disease biology, WIREs Mechanisms of Disease offers an unparalleled platform for learning and discovery.