TGCA COAD Multi-Omics Dataset — Processed Expression, Mutation, and Clinical Data

This dataset comprises multi-omics data for colorectal adenocarcinoma (COAD) derived from The Cancer Genome Atlas (TGCA). The archive preserves the original folder structure and includes the following modality-specific subdirectories:

– Clinical: Patient-level clinical metadata including demographics, tumor stage, and treatment history.
– RNAseq: Processed gene expression matrices in TPM or FPKM-normalized format.
– Mutation: Somatic variant call format (VCF) and MAF (Mutation Annotation Format) files.
– CNV: Copy number variation data including segment-level and gene-level copy number calls.
– Methylation: DNA methylation beta values from Illumina 450k or EPIC arrays.
– miRNA: Processed microRNA expression profiles.
– RPPA: Reverse-Phase Protein Array data for protein-level quantification.
– barcode: Sample barcode mapping files linking aliquots to patients.
– cert: (Optional) Certificate or metadata documentation files.

All data has been preprocessed and harmonized to support downstream machine learning and statistical analyses. This dataset is intended for academic and research use only. Users are expected to comply with TGCA data use policies and acknowledge the original data source appropriately.

Data source: The Cancer Genome Atlas (TCGA), hosted by the National Cancer Institute (NCI).
Researcher: Indrajeet Swain
Publication date: April 2026