SCHOLARLY PUBLICATION ✓ Open Access

A Chlorin-Based Nanoscale Metal–Organic Framework for Photodynamic Therapy of Colon Cancers

Kuangda Lu, Chunbai He, Wenbin Lin

📖 Journal of the American Chemical Society → 📅 2015-06-12 🔗 DOI: 10.1021/jacs.5b04069

View Journal Profile → ⬇ Download PDF View Official Paper ↗

📄 Abstract

We report here the rational design of the first chlorin-based nanoscale metal-organic framework (NMOF), DBC-UiO, with much improved photophysical properties over the previously reported porphyrin-based NMOF, DBP-UiO. Reduction of the DBP ligands in DBP-UiO to the DBC ligands in DBC-UiO led to a 13 nm red shift and an 11-fold increase in the extinction coefficient of the lowest-energy Q band. While inheriting the crystallinity, stability, porosity, and nanoplate morphology of DBP-UiO, DBC-UiO sensitizes more efficient (1)O2 generation and exhibits significantly enhanced photodynamic therapy (PDT) efficacy on two colon cancer mouse models as a result of its improved photophysical properties. Both apoptosis and immunogenic cell death contributed to killing of cancer cells in DBC-UiO-induced PDT.

📄 Abstract

📤 Share this page

🔬 Related Research Papers

Microfluidic Fabrication of Monodisperse Biocompatible and Biodegradable Polymersomes with Controlled Permeability

A Perfectly Hydrophobic Surface (θ A /θ R = 180°/180°)

Fine-Tuned Photoactive and Interconnection Layers for Achieving over 13% Efficiency in a Fullerene-Free Tandem Organic Solar Cell

A Versatile Kinetics-Controlled Coating Method To Construct Uniform Porous TiO2 Shells for Multifunctional Core–Shell Structures

Direct In situ Observation of Li2O Evolution on Li-Rich High-Capacity Cathode Material, Li[NixLi(1–2x)/3Mn(2–x)/3]O2 (0 ≤ x ≤0.5)

Ex Situ Generation of Stoichiometric and Substoichiometric 12CO and 13CO and Its Efficient Incorporation in Palladium Catalyzed Aminocarbonylations

Serial Ligand Catalysis: A Highly Selective Allylic C−H Oxidation

Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic

Highly Enantioselective Direct Conjugate Addition of Ketones to Nitroalkenes Promoted by A Chiral Primary Amine−Thiourea Catalyst

Hydrogen Storage in a Prototypical Zeolitic Imidazolate Framework-8

Grain-Boundary-Rich Copper for Efficient Solar-Driven Electrochemical CO 2 Reduction to Ethylene and Ethanol

Acid-Resistant Mesoporous Metal–Organic Framework toward Oral Insulin Delivery: Protein Encapsulation, Protection, and Release