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Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment

Maria Volkova, Raymond R. Russell

📖 Current Cardiology Reviews → 📅 2012-02-14 🔗 DOI: 10.2174/157340311799960645

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📄 Abstract

Anthracyclines, such as doxorubicin and idarubicin, remain an important class of chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart failure. In this review, we discuss the pathogenesis and incidence of anthracycline-induced cardiotoxicity as well as methods to detect, prevent and treat the condition.

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