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SCHOLARLY PUBLICATION ✓ Open Access

CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer

Malachi Griffith, Nicholas C. Spies, Kilannin Krysiak, Joshua F. McMichael, Adam C. Coffman, Arpad M. Danos, Benjamin J. Ainscough, Cody A. Ramirez, Damian Tobias Rieke, Lynzey Kujan, Erica Kay Barnell, Alex Handler Wagner, Zachary L. Skidmore, Amber Z. Wollam, Connor J. Liu, Martin R. Jones, Rachel L Bilski, Robert Lesurf, Yan-Yang Feng, Nakul M. Shah, Melika Bonakdar, Lee Trani, Matthew K. Matlock, Avinash Ramu, Katie Marie Campbell, Gregory C Spies, Aaron Graubert, Karthik Gangavarapu, James M. Eldred, David E. Larson

📖 Nature Genetics → 📅 2017-01-31 🔗 DOI: 10.1038/ng.3774
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📄 Abstract

Abstract CIViC is an expert crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer ( www.civicdb.org ) describing the therapeutic, prognostic, and diagnostic relevance of inherited and somatic variants of all types. CIViC is committed to open source code, open access content, public application programming interfaces (APIs), and provenance of supporting evidence to allow for the transparent creation of current and accurate variant interpretations for use in cancer precision medicine.

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