Cross-linking in Hydrogels – A Review

Hydrogels represent a class of high water content polymers with physical or chemical crosslinks. Their physical properties are similar to soft tissues. Cross linking is a stabilization process in polymer chemistry which leads to multidimensional extension of polymeric chain resulting in network structure. Cross-link is a bond which links one polymer chain to other. It can be ionic or covalent. Cross linking changes a liquid polymer into ‘solid’ or ‘gel’ by restricting the ability of movement. When polymer chains are linked together by cross-links, they lose some of their ability to move as individual polymer chains. A liquid polymer (where the chains are freely flowing) can be turned into a ‘solid’ or ‘gel’ by cross-linking the chains together. Cross linking increases the molecular mass of a polymer. Cross-linked polymers are important because they are mechanically strong and resistant to heat, wear and attack by solvents. However, the drawback associated with cross-linked polymers is that they are relatively inflexible when it comes to their processing properties because they are insoluble and infusible.