ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum

tional.However, classified as G1 or G2, Si-NENs are often discovered at an advanced disease stage -regional disease (36%) and distant metastasis (48%) are present -and percutaneous biopsy of a liver lesion is often the diagnostic procedure performed [2,7] .Previous ENETS guidelines [1, 8, 9] have discussed extensively the clinical symptomology, diagnosis and treatment of localized, regionalized as well as distant Si-NENs.This fourth edition of the ENETS guidelines is an update of the third version for the management of patients with Si-NENs published in 2012 [1] in order to further standardize and improve the early diagnosis and treatment of Si-NEN patients.This guideline deals with non-meta-