SCHOLARLY PUBLICATION ✓ Open Access

fastsimcoal: a continuous-time coalescent simulator of genomic diversity under arbitrarily complex evolutionary scenarios

Laurent Excoffier, Matthieu Foll

📖 Bioinformatics → 📅 2011-03-12 🔗 DOI: 10.1093/bioinformatics/btr124

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📄 Abstract

MOTIVATION: Genetic studies focus on increasingly larger genomic regions of both extant and ancient DNA, and there is a need for simulation software to match these technological advances. We present here a new coalescent-based simulation program fastsimcoal, which is able to quickly simulate a variety of genetic markers scattered over very long genomic regions with arbitrary recombination patterns under complex evolutionary scenarios. AVAILABILITY AND IMPLEMENTATION: fastsimcoal is a C++ program compiled for Windows, MacOsX and Linux platforms. It is freely available at cmpg.unibe.ch/software/fastsimcoal/, together with its detailed user manual and example input files.

📄 Abstract

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