Heterogeneous Asymmetric Catalysis with Homochiral Metal–Organic Frameworks: Network‐Structure‐Dependent Catalytic Activity

It’s all in the preparation: Heterogeneous asymmetric catalysts based on two homochiral highly porous metal–organic frameworks formed from the same building blocks show remarkably different activity. Although both catalysts are based on twofold interpenetrated structures, one catalyzes the addition of diethylzinc to aromatic aldehydes with high enantioselectivity (up to 90 % ee), while the other is inactive.