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SCHOLARLY PUBLICATION ✓ Open Access

Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice

Brian J Cummings, Nobuko Uchida, Stanley J. Tamaki, Desirée L. Salazar, Mitra J. Hooshmand, Robert G. Summers, Fred H. Gage, Aileen J. Anderson

📖 Proceedings of the National Academy of Sciences → 📅 2005-09-19 🔗 DOI: 10.1073/pnas.0507063102
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📄 Abstract

We report that prospectively isolated, human CNS stem cells grown as neurospheres (hCNS-SCns) survive, migrate, and express differentiation markers for neurons and oligodendrocytes after long-term engraftment in spinal cord-injured NOD-scid mice. hCNS-SCns engraftment was associated with locomotor recovery, an observation that was abolished by selective ablation of engrafted cells by diphtheria toxin. Remyelination by hCNS-SCns was found in both the spinal cord injury NOD-scid model and myelin-deficient shiverer mice. Moreover, electron microscopic evidence consistent with synapse formation between hCNS-SCns and mouse host neurons was observed. Glial fibrillary acidic protein-positive astrocytic differentiation was rare, and hCNS-SCns did not appear to contribute to the scar. These data suggest that hCNS-SCns may possess therapeutic potential for CNS injury and disease.

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