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SCHOLARLY PUBLICATION

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

Joshua R. Dunetz, Javier Magano, Gerald A. Weisenburger

📖 Organic Process Research & Development 📅 2015-11-15 🔗 DOI: 10.1021/op500305s
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📄 Abstract

This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.

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