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Maleimide Cross‐Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross‐Linking for Cell Encapsulation and In Situ Delivery

Edward A. Phelps, Nduka O. Enemchukwu, Vincent F. Fiore, Jay C. Sy, Niren Murthy, Todd A. Sulchek, Thomas Harrison Barker, Andrés J. Garcı́a

📄 Abstract

Engineered polyethylene glycol-maleimide matrices for regenerative medicine exhibit improved reaction efficiency and a wider range of Young’s moduli by utilizing maleimide cross-linking chemistry. This hydrogel chemistry is advantageous for cell delivery due to the mild reaction that occurs rapidly enough for in situ delivery, while easily lending itself to “plug-and-play” design variations such as incorporation of enzyme-cleavable cross-links and cell-adhesion peptides.

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