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NCCN Guidelines Insights: Rectal Cancer, Version 6.2020

Al B. Benson, Alan Paul Venook, Mahmoud M. Al-Hawary, Mustafa A. Arain, Yi‐Jen Chen, Kristen Keon Ciombor, Stacey A. Cohen, Harry S. Cooper, Dustin A. Deming, Ignacio Garrido‐Laguna, Jean L. Grem, Andrew Gunn, Sarah E. Hoffe, Joleen Marie Hubbard, Steven R. Hunt, Natalie N. Kirilcuk, Smitha Krishnamurthi, Wells A. Messersmith, Jeffrey A. Meyerhardt, Eric David Miller, Mary F. Mulcahy, Steven J. Nurkin, Michael James Overman, Aparna R. Parikh, Hitendra Patel, Katrina Sophia Pedersen, Leonard B. Saltz, Charles John Schneider, David Shibata, John Michael Skibber

📄 Abstract

The NCCN Guidelines for Rectal Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with rectal cancer. These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guidelines. These updates include clarifying the definition of rectum and differentiating the rectum from the sigmoid colon; the total neoadjuvant therapy approach for localized rectal cancer; and biomarker-targeted therapy for metastatic colorectal cancer, with a focus on new treatment options for patients with BRAF V600E- or HER2 amplification-positive disease.

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