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SCHOLARLY PUBLICATION ✓ Open Access

NetPath: a public resource of curated signal transduction pathways

Kumaran Kandasamy, S Sujatha Mohan, Rajesh Raju, Shivakumar Keerthikumar, Ghantasala S. Sameer Kumar, Abhilash K Venugopal, Deepthi Telikicherla, J. Daniel Navarro, Suresh Mathivanan, Christian Pecquet, Sashikanth Gollapudi, Sudhir Gopal Tattikota, Shyam Mohan, Hariprasad Padhukasahasram, Yashwanth Subbannayya, Renu Goel, Harrys K.C. Jacob, Jun Zhong, Raja Sekhar Nirujogi, Vishalakshi Nanjappa, Lavanya Balakrishnan, Roopashree Subbaiah, YL Ramachandra, B. A. Rahiman, Thottethodi Subrahmanya Keshava Prasad, Jian‐Xin Lin, Jon C. D. Houtman, Stephen V. Desiderio, Jean‐Christophe Renauld, Stefan N. Constantinescu

📄 Abstract

We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes – all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.

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