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Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier

Wei Wei, Guanghui Ma, Gang Hu, Di Yu, Tom C. B. McLeish, Zhiguo Su, Zheyu Shen

📖 Journal of the American Chemical Society → 📅 2008-11-04 🔗 DOI: 10.1021/ja8039585

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📄 Abstract

One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.

📄 Abstract

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