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Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

John G. Doench, Ella Hartenian, Daniel B. Graham, Zuzana Tóthová, Mudra Hegde, Ian C. P. Smith, Meagan E. Sullender, Benjamin L. Ebert, Ramnik J. Xavier, David E. Root

📖 Nature Biotechnology → 📅 2014-09-03 🔗 DOI: 10.1038/nbt.3026
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