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Rational Design of Molecular Fluorophores for Biological Imaging in the NIR‐II Window

Qinglai Yang, Zhuoran Ma, Huasen Wang, Bin Zhou, Shoujun Zhu, Yeteng Zhong, Junying Wang, Hao Wan, Alexander L. Antaris, Rui Ma, Xiao Zhang, Xiao Zhang, Jingyi Yang, Xiaodong Zhang, Xiaodong Zhang, Haitao Sun, Weiqiang Liu, Yongye Liang, Hongjie Dai

📄 Abstract

A new design for second near-infrared window (NIR-II) molecular fluorophores based on a shielding unit-donor-acceptor-donor-shielding unit (S-D-A-D-S) structure is reported. With 3,4-ethylenedioxy thiophene as the donor and fluorene as the shielding unit, the best performance fluorophores IR-FE and IR-FEP exhibit an emission quantum yield of 31% in toluene and 2.0% in water, respectively, representing the brightest organic dyes in NIR-II region reported so far.

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