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Scalable, Electrochemical Oxidation of Unactivated C–H Bonds

Yu Kawamata, Ming Yan, Zhiqing Liu, Deng‐Hui Bao, Jinshan Chen, Jeremy T. Starr, Phil S. Baran

📖 Journal of the American Chemical Society → 📅 2017-05-16 🔗 DOI: 10.1021/jacs.7b03539

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📄 Abstract

A practical electrochemical oxidation of unactivated C-H bonds is presented. This reaction utilizes a simple redox mediator, quinuclidine, with inexpensive carbon and nickel electrodes to selectively functionalize “deep-seated” methylene and methine moieties. The process exhibits a broad scope and good functional group compatibility. The scalability, as illustrated by a 50 g scale oxidation of sclareolide, bodes well for immediate and widespread adoption.

📄 Abstract

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