The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy

Abstract: Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RAS V12 and was later widely investigated as an inducer of ferroptosis. Ferroptosis is a recently discovered form of cell death caused by peroxidation induced by the accumulation of intracellular lipid reactive oxygen species (L-ROS) in an iron-dependent manner. Erastin can mediate ferroptosis through a variety of molecules including the cystine-glutamate transport receptor (system X C − ), the voltage-dependent anion channel (VDAC), and p53. Erastin is able to enhance the sensitivity of chemotherapy and radiotherapy, suggesting a promising future in cancer therapy. We hope that this review will help to better understand the role of erastin in ferroptosis and lay the foundation for further research and the development of erastin-based cancer therapies in the future. Keywords: erastin, ferroptosis, system X C − , p53, VDAC, cancer