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SCHOLARLY PUBLICATION ✓ Open Access

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

Bahare Salehi, Shashi Upadhyay, İlkay Erdoğan Orhan, Arun Kumar Jugran, Sumali Lakmini Dissanayake Jayaweera, Daniel Anthony Dias, Farukh S. Sharopov, Yasaman Taheri, Natália Alves Martins, Navid Baghalpour, William Chi Shing Cho, Javad Sharifi‐Rad

📄 Abstract

α- and β-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of α- and β-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.

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