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Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes

Denis Prat, Olivier Pardigon, Hans‐Wolfram Flemming, Sylvie Letestu, Véronique Ducandas, Pascal Isnard, Eberhard Guntrum, Thomas Senac, Stéphane Ruisseau, Paul Cruciani, Patrik Hosek

📖 Organic Process Research & Development 📅 2013-11-04 🔗 DOI: 10.1021/op4002565

📄 Abstract

Sanofi’s solvent selection guide helps chemists in early development select sustainable solvents that will be accepted in all production sites. Solvents are divided into four classes, from “recommended” to “banned”. This ranking is derived from Safety, Health, Environmental, Quality, and Industrial constraints. Each solvent has its own ID card that indicates the overall ranking, H, S & E hazard bands, as well as its ICH limit, physical properties, cost, and substitution advice.

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