Helmut Sies
Leibniz Institute of Environmental Medicine
Helmut Sies is a German physician, biochemist and university professor. He was the first to demonstrate the existence of hydrogen peroxide as a normal attribute of aerobic life in 1970, and he introduced the concept of Oxidative stress in 1985. He also worked on the biological strategies of antioxidant defense and the biochemistry of nutritional antioxidants.
Read biography ↓Biography, research & contributions
Helmut Sies is a German physician, biochemist and university professor. He was the first to demonstrate the existence of hydrogen peroxide as a normal attribute of aerobic life in 1970, and he introduced the concept of Oxidative stress in 1985. He also worked on the biological strategies of antioxidant defense and the biochemistry of nutritional antioxidants.
Affiliation
Leibniz Institute of Environmental Medicine
Top Publications
- Hydroperoxide metabolism in mammalian organs. (1979) - 5,862 citations
- Reactive oxygen species (ROS) as pleiotropic physiological signalling agents (2020) - 5,343 citations
- Oxidative stress: oxidants and antioxidants (1997) - 4,591 citations
- Oxidative Stress (2017) - 3,554 citations
- Oxidative stress: a concept in redox biology and medicine (2015) - 3,049 citations
At a glance
- Full name
- Helmut Sies
- ORCID
- 0000-0002-1000-3198
- OpenAlex ID
- https://openalex.org/A5091525666
Research interests
- Redox biology and oxidative stress, Antioxidant Activity and Oxidative Stress, Phytochemicals and Antioxidant Activities, Nitric Oxide and Endothelin Effects, Glutathione Transferases and Polymorphisms
Research topics
Education
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Selected research & further reading
A curated reading list, not a ranking by citation count. References use DOI metadata, matching public scholarly records or authoritative lecture sources.
See the source-linked reading and original works in the research guide above.
Citation & publication trends
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Source: OpenAlex · Retrieved 2026-10-07. Metrics are database-specific and are not a scientific ranking.
Most-cited linked publications
Publications matched across ORCID and OpenAlex. Citation counts are source-specific.
- Hydroperoxide metabolism in mammalian organs. ↗1979 · Physiological Reviews5,862OpenAlex citations
- Reactive oxygen species (ROS) as pleiotropic physiological signalling agents ↗2020 · Nature Reviews Molecular Cell Biology5,343OpenAlex citations
- Oxidative stress: oxidants and antioxidants ↗1997 · Experimental Physiology4,591OpenAlex citations
- Oxidative Stress ↗2017 · Annual Review of Biochemistry3,554OpenAlex citations
- Oxidative stress: a concept in redox biology and medicine ↗2015 · Redox Biology3,049OpenAlex citations
Recent linked publications
Publications matched across ORCID and OpenAlex. Citation counts are source-specific.
- Hydroperoxide metabolism in mammalian organs. ↗1979 · Physiological Reviews
- Reactive oxygen species (ROS) as pleiotropic physiological signalling agents ↗2020 · Nature Reviews Molecular Cell Biology
- Oxidative stress: oxidants and antioxidants ↗1997 · Experimental Physiology
- Oxidative Stress ↗2017 · Annual Review of Biochemistry
- Oxidative stress: a concept in redox biology and medicine ↗2015 · Redox Biology
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Institutions
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Awards & honors
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Career timeline
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Co-authors
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Education & career institution links
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Sign in to claim this profileSources & data information
Editorial review: 2026-10-07 · Last data update: 2026-10-07 20:36:15
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